Parabilis Medicines

Principal Associate Scientist, Biology

Cambridge · Principal

Sponsorship not specified$108k-$128kDetected 40 days ago

Node.jsPharmacologyqPCRCRISPRMolecular BiologyResearchWestern BlottingCommunicationCollaborationMentoring

About the role

The company has pioneered a new class of alpha-helical peptides - Helicons™ - capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines.
Zolucatetide is being evaluated in the clinic across multiple Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications.
Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact.

Design and execute target engagement and mechanism-of-action studies to characterize novel therapeutic candidates
Develop cell-based assays (e.g., NanoBRET, HiBiT, AlphaLISA, HTRF) from conceptualization and proof-of-concept through to validated implementation in collaboration with internal or external cell pharmacology team
Perform and interpret supporting assays including qPCR, Western blotting, immunoprecipitation, and pulldown assays
Independently manage experimental workflows, anticipate technical challenges, and drive projects to completion
Maintain high standards of data integrity, documentation, and experimental reproducibility
Deep expertise in developing and executing cell-based assays (e.g., NanoBRET, HiBiT, AlphaLISA, HTRF)
Demonstrated ability to independently design, execute, and interpret experiments

Proficiency in molecular and biochemical techniques including qPCR, Western blotting, immunoprecipitation, and pulldown assays
Experience with cell line engineering (CRISPR/Cas9, viral expression systems)
Ability to critically evaluate complex datasets, resolve discrepancies, and communicate clear conclusions to cross-functional stakeholders
Intellectual curiosity, proactively identifying opportunities to deepen expertise or explore new approaches

Experience with induced proximity or targeted protein degradation approaches
Experience in oncology drug discovery
We're inventing a new class of medicines-one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug.
Our work requires us to be curious, humble and adaptable.
In(ter)dependent.
Patient-focused.
We're All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.
Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients.

The base salary range for this position is $108,000-$128,000 per year, depending on experience, qualifications, and internal practices.
Parabilis's total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees' overall well-being.

Education & Experience
The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.

This listing is sourced directly from Parabilis Medicines's careers page and normalized into a canonical job model.