Kymera Therapeutics

Kymera Therapeutics

Senior Infrastructure and Systems Engineer

Watertown, MA · Senior

Sponsorship not specified$115k-$200kDetected 5 days ago
PowerShellAzureCybersecurityMicrosoft DefenderIncident ResponseSystems EngineeringDNSFirewallVPNCiscoZero TrustResearchLeadershipCollaborationMicrosoft TeamsSharePoint

About the role

  • Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics.
  • For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn.
  • Our goals are shared, our decisions data-driven and our camaraderie genuine. - BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

Responsibilities

  • Architect, implement, and maintain enterprise endpoint management solutions using Microsoft Intune and Company Portal
  • Design and maintain application deployment strategies utilizing Win32 packaging, Microsoft Store integration, Microsoft 365 Apps, and PowerShell automation
  • Develop and maintain configuration profiles, compliance policies, security baselines, remediation scripts, and update rings
  • Engineer and optimize Windows Autopilot deployments including Enrollment Status Page (ESP) configurations, provisioning workflows, Windows Hello for Business, and lifecycle management
  • Develop standards for endpoint configuration, provisioning, and device governance
  • Lead initiatives to modernize endpoint management through cloud-native technologies
  • Support macOS and iPadOS devices in an enterprise MDM context alongside Windows.
  • Serve as L3 escalation point for the deskside support team, building on prior work rather than re-diagnosing from scratch
  • Engineer and support Windows 11 enterprise platforms with a focus on performance, reliability, and security
  • Perform deep operating system analysis including boot performance, driver architecture, Windows servicing, registry, profile management, and application compatibility

Requirements

  • Advanced PowerShell scripting and Microsoft Graph API proficiency are core requirements.
  • The candidate must be able to read, maintain, extend, and build complex scripts and Graph API integrations from scratch including Azure Automation runbooks and scheduled operational tasks.

Compensation

  • $115k-$200k

Benefits

  • Create reporting dashboards and health monitoring scripts for endpoint compliance and operational metrics
  • Okta and Microsoft Entra ID administration including SSO integrations, enterprise application registrations, user provisioning, MFA policy management, and agent health monitoring across a hybrid identity environment

Company info

  • Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients' lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston's top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn.
  • How we work:
  • PIONEER: We are courageous, resilient and rigorous in our mission to improve patients' lives through our revolutionary degrader medicines.
  • COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
  • Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients' lives.
  • Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions.
  • Founded in 2016, Kymera has been recognized as one of Boston's top workplaces for the past several years.
  • BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.
  • Kymera Therapeutics is seeking a Senior Infrastructure & Systems Engineer to serve as a technical peer and force multiplier for the Senior Director of Infrastructure & Operations.
  • This role provides technical leadership for the organization's endpoint computing platform and broader infrastructure within a hybrid Microsoft ecosystem, serving as the senior engineering resource responsible for designing, implementing, securing, and optimizing endpoint management technologies while acting as the highest level of technical escalation for complex infrastructure issues.
  • The successful candidate will drive the evolution of Kymera's modern workplace by leveraging Microsoft Intune, Microsoft 365, Entra ID, Windows client engineering, automation, and cloud technologies to deliver secure, scalable, and highly available endpoint services.
  • This position partners closely with Infrastructure, Cybersecurity, Identity, and Enterprise Applications teams to modernize endpoint architecture, improve operational maturity, and implement engineering best practices across the organization.
  • The ideal candidate possesses a cloud-first engineering mindset while maintaining deep expertise across hybrid environments.
  • They understand enterprise systems as interconnected platforms rather than isolated technologies and are comfortable designing solutions that improve security, automation, and user experience across the enterprise.
  • The right candidate operates independently, takes strong ownership of their work, and is committed to reducing single points of failure through automation and documentation.
  • Core Responsibilities
  • Endpoint Engineering and Modern Device Management
  • Support macOS and iPadOS devices in an enterprise MDM context alongside Windows. A key opportunity within this role is to establish and mature Apple device management practices including MDM enrollment, compliance policies, and lifecycle management
  • Windows Systems Engineering

Visa & Work Authorization

  • veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class
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This listing is sourced directly from Kymera Therapeutics's careers page and normalized into a canonical job model.