Earli Inc.

Head of Translational Biology

Redwood City, CA · Exec

Sponsorship not specified$215k-$235kDetected 162 days ago

Computer VisionPharmacologyFDA RegulatoryCRISPRAnimal StudiesLeadershipCommunication

About the role

The successful candidate will have a proven track record of successfully initiating and managing pharmacology and translational science projects across oncology indications from Discovery through IND enabling studies.
This position will report to the Chief Scientific Officer.
Be the key external stakeholder to select and oversee CROs to conduct GLP safety and toxicology studies

Cancer cells become their own drug factories, enabling localized immune activation, even in cold tumors.
She/he will be responsible for working with the existing scientific leadership for the design and planning of in vivo preclinical studies to characterize the efficacy, PK/PD and safety of Earli's proprietary compounds.
Oversee and manage the Translational Biology group at Earli to support the growth and expansion of the team
Proactively foster the growth of team members and identify opportunities for staff to develop into top-tier, independent pharmacology team members
Ensure the production of high-quality technical reports including statistical analyses and data integrity review to support regulatory submissions
Proven track record leading nonclinical safety and PK strategies to support development of nucleic acid therapeutics through IND filing.
Significant experience working with CROs to design and execute external studies.
Significant experience in writing regulatory documentation to support IND filings.

Strong and documented first hand experience in leveraging standard oncology models such as syngeneic, orthotopic, metastatic and GEMM/transgenic cancer models for the use in therapeutics development
Successful demonstration of ability to rigorously analyze and interpret diverse, multidisciplinary data sets.
Previous experience in managing small to medium sized groups is required
Excellent verbal communication and interpersonal skills are required
As a key member that directly influences strategy, you must be able to think independently, effectively communicate and fully integrate into a high achieving team
Required Experience, Knowledge and Skills

DABT preferred, but not required.
Translatability of those results into human clinical use is highly desired.
Proven ability to oversee the development of new model systems.
Experience working with atypical and larger preclinical cancer models is a plus.

This listing is sourced directly from Earli Inc.'s careers page and normalized into a canonical job model.