Flagshippioneeringinc

Flagshippioneeringinc

Pioneering Medicines: Director, In Vivo Pharmacology - Metabolic Disease

Cambridge, MA USA · Director

Sponsorship not specified$172k-$237kDetected 7 days ago
ComplianceSupply ChainRecruitingPharmacologyResearchAnimal StudiesAnimal ModelsLeadershipCommunicationCollaborationMentoring

About the role

  • This key role will require an individual to direct and oversee in vivo pharmacology efforts, participating in drug discovery and early development activities.
  • The candidate will work in cross-functional teams leading and supporting the activities, delivering research leadership, and managing/mentoring junior scientists.
  • We are seeking individuals who are analytical, goal-oriented, and timeline-sensitive, while maintaining the highest of scientific and ethical standards.

Responsibilities

  • Identify and implement in vivo efficacy and PK/PD models to support assessment of lead small molecules, antibodies, peptides and genetic modalities, with a focus on disease-relevant endpoints, PD, and target-specific biomarkers
  • Participate in partnerships and collaboration efforts with Flagship Platform companies and external pharmaceutical partners
  • Collaborate closely across functions such as in vitro pharmacology, DMPK/Tox, and translational sciences to advance programs to development candidate and IND-enabling studies
  • Management of direct report/s to execute internal studies and manage studies at external CROs to achieve program goals
  • Contribute to discussions with internal project teams, external partners and consultants in developing comprehensive in vivo strategic plans
  • Work closely with other FSP companies to develop research strategies and evaluate new programs.
  • Pioneering Medicines is seeking a highly motivated and strategic Director of in vivo Pharmacology to support a growing portfolio of assets.
  • The role will involve functional accountability to support assets across a diverse range of modalities using their deep expertise in obesity and metabolic diseases.

Requirements

  • PhD + 10 or more years of industry experience or MS with 12+ years of industry experience within in vivo pharmacology or related discipline
  • Strong understanding of PK/PD assessments in models of disease
  • Experience in designing ex vivo studies to assess PD and target engagement endpoints, is a must-have.
  • Proficient experience using rodent metabolic and behavioral cage systems and metabolic phenotyping technologies
  • What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent.

Nice to have

  • In-depth hands-on expertise with in vivo models of obesity and metabolic diseases.
  • Cardiovascular experience preferred.
  • Experience and managing in vivo personnel in a dynamic and fast-paced research environment preferred.

Skills

  • Experience working with standard modalities, such as small molecules, antibodies and peptides desired.
  • Collaborative mindset and a willingness to work with different teams.
  • Experience with animal facility management, protocol writing, study reports, interactions with IACUC, and use of LIMS.
  • About Flagship
  • Experience comes in many forms, skills are transferable, and passion goes a long way.
  • California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information.
  • To exercise your rights or for questions, contact privacy@flagshippioneering.com.

Compensation

  • Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.
  • The salary range for this role is $172,000 - $236,500.

Benefits

  • vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
  • We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
  • Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.

Company info

  • The successful candidate is expected to proactively build and maintain strong collaborations with Flagship Pioneering platform companies and large pharma partners.
  • At Flagship, we recognize there is no perfect candidate.

Visa & Work Authorization

  • California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information.
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