Alltrna

Sr. Principal Scientist / Director, DMPK & Bioanalytical Sciences

Cambridge, Massachusetts, United States · Director

Sponsorship not specified$179k-$236kDetected 6 days ago

GCPComplianceRecruitingPharmacologyNGSScientific WritingResearchExperimental DesignMass SpectrometryProtein AnalysisLeadershipCollaborationWriting

About the role

For more information, visit www.alltrna.com The salary range for this role is $179,000 - $236,000.

Lead DMPK and bioanalytical strategy across nonclinical and clinical programs, including PK, biomarker, and translational PD readouts
Design, execute, and oversee PK and PK-PD studies of tRNAs to evaluate delivery technologies (LNP and others) and biomarker effects
Manage and qualify CRO and external lab partners across bioanalytical and PK programs
Support nonclinical toxicology programs in collaboration with internal teams and CROs
Author nonclinical sections of regulatory filings (e.g., IND) and briefing documents; support agency interactions and responses
Manage and develop direct report(s); collaborate with the broader pharmacology team
Reporting to the Chief Scientific Officer, this role leads DMPK and bioanalytical strategy across nonclinical and clinical programs, operating as a hands-on scientific leader.
This person will support pharmacology and nonclinical toxicology programs, providing broader context across the nonclinical development portfolio.
Strong scientific writing skills - regulatory documents (e.g., IND nonclinical sections) and internal study reports
Experience supervising and developing scientists

8+ years of industry experience in DMPK, bioanalytical sciences, or closely related function
Experience with a range of bioanalytical methods and their development, qualification, and validation in both nonclinical and clinical contexts (e.g. mass spectroscopy, ELISA, NGS, etc.)
Experience with ligand binding assays and multiplex immunoassay platforms (e.g., MSD, Luminex) for cytokine, immunogenicity, and biomarker analysis
Experience in translational or clinical biomarker development, including assay strategy and fit-for-purpose qualification
Lead method development, qualification, and validation for bioanalytical assays (GLP/GCP-compliant as required)
The ideal candidate brings deep scientific expertise and a hands-on approach and thrives in the fast-paced environment of a clinical-stage biotech where both scientific and strategic contributions are expected

Experience in rare disease, genetic medicine, or nucleic acid / RNA therapeutics
Familiarity with LNP platform biology and delivery landscape
Experience operating in a cross-functional leadership role at a clinical-stage biotech
Experience with LC-MS/MS or related mass spectrometry platforms
Alltrna is the first clinical-stage biotech company advancing tRNA medicines to address shared disease-causing mutations across many indications.
AP003 is being developed for the arginine-to-TGA (Arg-TGA) PTC in patients with liver Stop Codon Disease, including phenylketonuria, organic acidemias, and urea cycle disorders.
For more information, visit www.alltrna.com
Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience.

Alltrna currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.

and benefits information is based on Alltrna's good faith estimate as of the date of publication and may be modified in the future.

We are looking for an accomplished DMPK and bioanalytical scientist with experience in PK study design, bioanalytical method development, and translational biomarker strategy.

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