Amgen
Principal Scientist – Chemical Biology & Proximity-Based Therapeutics
US - California - Thousand Oaks · Principal
Sponsorship not specifiedDetected 8 hours ago
PharmacologyMolecular BiologyResearchCommunicationCollaborationPublic Speaking
> stay_score
odds of building a lasting career here
38Risky
Cap-exempt (no lottery)0
Sponsors this role85
Entry-level history0
PERM / green-card track0
Lottery odds40
Fits your clock70
Thin sponsorship signal and lottery-bound. A low-probability bet with your clock running. Prioritize cap-exempt roles and proven entry-level sponsors first.
Lottery odds assume a STEM candidate.
Personalize to your clock →> community_outcomes
No reports yet — be the first to help the next applicant.
About the role
- Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases.
- With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year.
- Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.
Responsibilities
- Lead discovery efforts using phenotypic screening and chemical genetics approaches to identify novel proximity-driven mechanisms
- Develop and apply disease-relevant cellular models to uncover actionable biology
- Design and implement phenotypic screening strategies to enable discovery of molecular glues and proximity-based modulators
- Develop and apply disease-relevant cellular models to capture functional biology
- Build and optimize high-content and high-throughput assays, including imaging-based and multi-parametric readouts
- Apply chemical genetics approaches to interrogate biological pathways and support target identification and validation
- Partner with cross-functional teams to advance discoveries from screening through early drug discovery
Requirements
- Doctorate degree in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field [and relevant post-doc where applicable] and 2 years of relevant industry experience
- Master's degree in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field and 5 years of relevant industry experience
- Bachelor's degree in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field and 7 years of relevant industry experience
Nice to have
- Strong expertise in chemical biology and small molecule discovery, with experience in proximity-based mechanisms, molecular glues, or related areas
- Experience working with disease-relevant cellular models
- Strong background in mechanism-of-action studies using cellular and molecular biology approaches
- Track record of scientific contributions (publications, patents, presentations)
- Excellent collaboration and communication skills in a matrixed research environment
- Experience with chemical genetics approaches in phenotypic discovery
- Familiarity with proteomics, transcriptomics, or systems biology approaches
- Experience supporting target identification or deconvolution from phenotypic screens
Compensation
- 140,123.35USD -189,578.65 USD
Company info
- Career Category Scientific Job Description Join Amgen's Mission of Serving Patients At Amgen, if you feel like you're part of something bigger, it's because you are.
- If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team.
- We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.
- We are all different, yet we all use our unique contributions to serve patients.
- We are seeking an exceptional Principal Scientist to lead discovery efforts at the intersection of chemical biology, induced proximity, and phenotypic drug discovery.
Equal opportunity
- Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
- Please contact us to request accommodation.
- We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
Visa & Work Authorization
- Sponsorship for this role is not guaranteed.
This listing is sourced directly from Amgen's careers page and normalized into a canonical job model.