Jade Biosciences
Principal Scientist, Immunology
Remote; San Francisco; Seattle · Principal
Sponsorship not specified$175k-$190kDetected 25 days ago
PharmacologyFlow CytometryResearchProtein AnalysisAnimal StudiesAnimal ModelsLeadershipCommunicationPublic Speaking
About the role
- The Research and Translational Medicine group at Jade is looking to add a Principal Scientist, Translational Research, to our team.
- The Principal Scientist will integrate literature, experimental data, and translational insights to strengthen program rationale, inform clinical development, and identify opportunities for pipeline expansion.
- This is an exciting opportunity to join a growing, highly collaborative biotech team and contribute to the advancement of potentially best-in-class therapies for autoimmune and inflammatory diseases.
Responsibilities
- Lead immunology-driven research strategy across pipeline programs to support scientific narrative and indication assessment, integrating literature, experimental data, and translational insights
- Design and oversee mechanism-of-action studies to elucidate target biology, pathway modulation, and disease relevance across in vitro, ex vivo, and in vivo models, executed in partnership with CROs
- Partner closely with Translational Medicine, Clinical Pharmacology, and Nonclinical teams to ensure alignment of preclinical findings with clinical strategy
- Identify and validate new targets and pathways for pipeline expansion, leveraging deep understanding of disease biology, emerging science, and internal platform capabilities
- Support external collaborations and CRO activities, providing scientific direction and technical oversight to ensure high-quality data generation
- Author and contribute to scientific documents, including study reports, regulatory sections (e.g., IND-enabling rationale), presentations, and publications
Requirements
- Strong written and verbal communication skills, with a track record of scientific publications and presentations
- Ability to operate independently while contributing to a collaborative, fast-paced biotech environment
- periodic travel to team and company events is required.
- Experience with immunological assays and platforms (e.g., flow cytometry, ELISA/MSD, cytokine panels, cellular assays); familiarity with advanced platforms (e.g., single-cell, proteomics) is a plus
Nice to have
- Generate and interpret complex datasets (e.g., cellular immunology, cytokine profiling, pathway analysis), ensuring rigorous and hypothesis-driven conclusions
- Evaluate and prioritize new indication opportunities, integrating mechanistic rationale, competitive landscape, and translational feasibility
- Present findings to internal governance teams and external scientific forums
- Stay current with advances in immunology, inflammation, and translational science, applying new insights to strengthen program and pipeline strategy
- PhD in Immunology or related field with 8-12+ years of relevant industry experience is required
- Deep expertise in immunology and disease biology, particularly in autoimmune and inflammatory disease mechanisms
- Strong understanding of drug development, including how preclinical and translational data inform clinical strategy
- Experience with immunological assays and platforms (e.g., flow cytometry, ELISA/MSD, cytokine panels, cellular assays)
Compensation
- The anticipated salary range for candidates for this role is $175,000 - $190,000.
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