Kiniksapharmaceuticals

Senior Scientist, In Vitro and In Vivo Pharmacology

Lexington, MA · Senior

Sponsorship not specified$167k-$174kDetected 9 days ago

PharmacologyFDA RegulatoryMolecular BiologyResearchAnimal StudiesLeadershipCommunicationCollaboration

About the role

Grounded in rigorous science and bold innovation, the company fosters a highly collaborative, patient‑first culture led by accomplished life sciences leaders.
At Kiniksa, talented individuals are trusted and empowered to make a real impact-shaping the future of medicine while improving the lives of patients who need it most.
Kiniksa is seeking a highly motivated Senior Scientist, In Vitro and In Vivo Pharmacology reporting to GVP, Research & Non-Clinical Development to join our Research organization.

Design, execute, and interpret in vitro pharmacology studies to support target validation, lead characterization, and clinical-stage development programs.
Develop mechanistic assays evaluating target engagement, receptor occupancy, signaling pathways, cytokine modulation, immune cell activation, and pharmacodynamic responses.
Establish and optimize cell-based and biochemical assays using primary cells, immortalized cell lines, co-culture systems, and in vivo disease-relevant models.
Generate data packages that support candidate selection, indication prioritization, dose selection rationale, and clinical biomarker strategies.
Collaborate with external CROs, academic investigators, and clinical collaborators.
Author technical reports, study protocols, scientific publications, regulatory support documents, and presentations.
Hands-on experience developing and optimizing cell-based and mechanistic assays.
Kiniksa Pharmaceuticals is a commercial‑stage biopharmaceutical company developing and commercializing novel therapies for diseases with unmet need, with a focus on cardiovascular indications.
With deep expertise in immunology and inflammation, Kiniksa is advancing a growing portfolio of approved and investigational medicines, anchored by its lead product, ARCALYST®, the first and only FDA‑approved therapy for recurrent pericarditis.

Typically 5+ years of relevant biotechnology or pharmaceutical industry experience.
Demonstrated experience supporting discovery and translational development of biologic therapeutics.
Experience working within cross-functional drug development teams from early research through clinical development.

Strong experience with in vitro and in vivo pharmacology studies.
Expertise in immunology, inflammation, and biologic drug development.
Ability to analyze complex scientific data and translate findings into actionable insights.
Strong collaboration and communication skills within cross-functional drug development teams.

Compensation decisions are based on objective criteria including role responsibilities, experience/qualifications, internal equity, geographic location, and external market benchmarks.
decisions are based on objective criteria including role responsibilities, experience/qualifications, internal equity, geographic location, and external market benchmarks.

This listing is sourced directly from Kiniksapharmaceuticals's careers page and normalized into a canonical job model.