Korro Bio
(Contract) Research Associate, In Vivo Pharmacology
60 First St, Cambridge, MA 02141
Sponsorship not specifiedDetected 27 days ago
Data AnalysisExcelCustomer SupportPharmacologyClinical Laboratory TechniquesPCRqPCRMolecular BiologyCell CultureResearchProtein AnalysisAnimal StudiesCommunicationProblem SolvingPublic SpeakingMicrosoft Office
About the role
- By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability.
- Korro is based in Cambridge, Massachusetts.
- They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work.
Responsibilities
- Perform dosing via subcutaneous (SC), intraperitoneal (IP) and intravenous (IV) routes
- Provide overall in vivo and ex vivo technical support for projects working to advance one or more experimental therapeutic compounds.
- Develop, optimize, and execute ELISA and hELISA assays to quantify target proteins, biomarkers and therapeutic candidates in biological matrices.
- Support bioanalytical method development activities for the measurement of drug concentrations and pharmacodynamic endpoints in plasma, serum, and tissue samples.
- Collaborate cross functionally with Discovery Chemistry, Translational Biology, and DMPK teams to support exposure response analyses and inform compound progression decisions.
- Maintain meticulous records of all experimental procedures, raw data, and results in electronic laboratory notebooks (ELN).
- Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform.
- Korro is generating a portfolio of differentiated programs that are designed to harness the body's natural RNA editing process to effect a precise yet transient single base edit.
Requirements
- Bachelor's degree in Biology, Biochemistry, Pharmacology, or a related life sciences discipline with 0-2 years' experience.
- Knowledge of tissue processing and molecular biology methods including RNA purification, PCR, qPCR, sequencing, protein isolation, MSD, western blot.
- Proficiency in standard laboratory techniques including cell culture, aseptic technique, and sterile handling of biological samples.
- Experience with data analysis and visualization software such as Graph Pad Prism, Microsoft Office (including Excel) for summarizing and presenting pharmacology and bioanalytical data.
- Familiarity with electronic laboratory notebooks (ELN) for data recording and experiment documentation.
Nice to have
- Knowledge of cardiometabolic/obesity models or experience with rodent models requiring low-stress handling is highly desirable.
- Experience with bioanalytical method development and execution in support of in vivo and in vitro pharmacology or ADME studies is a plus.
Compensation
- Benefits: Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending acc
Benefits
- We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases.
- Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.
- monitor animal health, collect blood samples, harvest multiple tissues, and coordinate sample storage and analysis.
Company info
- We are collaborative and united by a common mission.
- Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization.
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