Insitro

Insitro

Associate Scientist III, Cardiac Modeling

South San Francisco, CA · Mid

Sponsorship not specified$107k-$114kDetected 31 days ago
Machine LearningExcelPCRqPCRCRISPRCell CultureProtein AnalysisWestern BlottingCommunicationPublic Speaking

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odds of building a lasting career here

46Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role76
Entry-level history0
PERM / green-card track0
Lottery odds (Level II)66
Fits your clock70

Sponsors, but it's cap-subject — you still face the weighted lottery (~30% per draw at Level II). Good if you win; have a cap-exempt backup on your list.

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Files H-1B transfers

1 transfer filing in the last year, covering 1 worker. Median labor-condition decision: 7 days. An employer that already files transfers is one that can take over an existing H-1B.

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About the role

  • insitro is a physical AI company dedicated to unlocking causal human biology and accelerating the delivery of better medicines to patients.
  • Our unique Virtual Human™ platform identifies novel, high-impact genetic intervention points, which our TherML™ platform translates into therapeutics-whether small molecules, biologics, or oligos.
  • With multiple programs in metabolic disease and neuroscience advancing toward the clinic, and our first IND submission slated for the second half of this year, we are at a pivotal inflection point.

Responsibilities

  • Differentiation & QC: Support the generation and maintenance of iPSC lines and their differentiation into cardiomyocytes in 2D format (monolayers), implementing rigorous quality control points at each stage of the pipeline and with emphasis on production scalability
  • Genetic Disease Models: Assist in building isogenic iPSC-CM disease models - including patient and CRISPR-edited lines carrying disease-associated variants - and characterizing the cellular model to study cardiovascular pathophysiology
  • Functional Readouts: Support the development and optimization of functional assays relevant to cardiovascular disease -contractility, electrophysiology, calcium handling, stress responses, high-content imaging - in formats compatible with high-throughput data acquisition
  • Genetic Disease Modeling: Previous experience developing genetic iPSC-CM disease models - patient-derived lines, CRISPR-edited isogenic pairs - to study cardiovascular mechanisms
  • We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease.
  • These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience and metabolism.
  • Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners.

Requirements

  • A bachelor's or master's degree in biology, biochemistry, or related discipline with at least 2 years of relevant experience in the biotech/biopharma industry
  • Cell culture and iPSC-CM Expertise:
  • Deep hands-on experience in iPSC culture, cardiac directed differentiation and iPSC-CM model characterization in 2D (monolayer) format.
  • Experience with functional assays relevant to cardiomyocyte biology (contractility, calcium, electrophysiology, imaging, stress responses).
  • Hands-on expertise in molecular assays, such as PCR, RT-qPCR, Western Blot and immunofluorescence
  • Track record of executing rigorous experiments and communicating findings clearly in publications, presentations or internal reports
  • Genetic Disease Modeling:
  • Previous experience developing genetic iPSC-CM disease models - patient-derived lines, CRISPR-edited isogenic pairs - to study cardiovascular mechanisms
  • Scientific Communication:

Nice to have

  • Cell culture and iPSC-CM Expertise: Deep hands-on experience in iPSC culture, cardiac directed differentiation and iPSC-CM model characterization in 2D (monolayer) format.
  • Prior experience in 3D/engineered heart tissue platforms or organoids is a plus
  • Cardiovascular Biology: Background in cardiomyocyte biology and/or cardiovascular disease is preferred
  • Functional Assays: Experience with functional assays relevant to cardiomyocyte biology (contractility, calcium, electrophysiology, imaging, stress responses).
  • Prior exposure and experience working with high-throughput platforms and/or automated systems is a plus
  • Background in cardiomyocyte biology and/or cardiovascular disease is preferred

Compensation

  • Our target starting salary for successful US-based applicants for this role is $107,000 - $114,000.
  • To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity.
  • This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

Benefits

  • Excellent medical, dental, and vision coverage as well as mental health and well-being support
  • Open, flexible vacation policy
  • Paid parental leave of at least 16 weeks to support parents who give birth, and 10 weeks for a new parent (inclusive of birth, adoption, fostering, etc)
  • New hire stipend for home office setup
  • Monthly cell phone & internet stipend
  • All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
  • We believe diversity, equity, and inclusion need to be at the foundation of our culture.
  • insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines.
  • Access to a free commuter bus network that provides transport to and from our South San Francisco HQ from locations all around the Bay Area

Company info

  • We are seeking an Associate Scientist III to join our cardiac disease biology team.

Equal opportunity

  • insitro is an equal opportunity employer.
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This listing is sourced directly from Insitro's careers page and normalized into a canonical job model.