Twist Bioscience
Senior Computational Scientist
USA - South San Francisco, CA · Senior
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odds of building a lasting career here
Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
Personalize to your clock →H-1B wage level
the lottery is wage-weighted — each level is one more entry
$24,436 more — $175,136 — moves this role to Level IV and 4 lottery entries. That figure is inside the range the employer already advertised.
Based on the DOL prevailing wage for this occupation and worksite, a base salary of $175,136 would place this position at wage Level IV. That figure is within the posted range, and I'd like to target it. This role classifies under "Biological Scientists, All Other" for prevailing-wage purposes.
DOL prevailing wage, 2026-27 wage year · Biological Scientists, All Other (19-1029) · San Francisco-Oakland-Fremont, CA. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
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Sourced from Department of Labor LCA, PERM and prevailing-wage disclosure data. Employer matching is by name, so figures may be split across an employer's legal entities. Absence of a filing means none appears in our copy of the data, not that none exists.
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About the role
- You will work across computational biology, machine learning, and experimental science, collaborating with research scientists, software engineers, and customer-facing teams.
- Candidates with relevant experience in other therapeutic proteins are encouraged to apply.
Responsibilities
- Develop algorithms that integrate protein sequences with NGS and experimental data to derive insights that inform subsequent experiments and design cycles.
- Identify high-impact opportunities for new algorithms and AI-enabled capabilities, lead their development from concept through experimental validation, and translate successful approaches into reusable tools for research programs.
- Develop AI/ML methods for designing, evaluating, and optimizing therapeutic protein sequences.
- Partner with software and bioinformatics teams to integrate models and analytical workflows into scalable research systems.
- Lead computational analyses for protein discovery programs, including sequence selection, clone prioritization, and characterization.
- Collaborate across computational, experimental, engineering, and customer-facing teams to translate scientific needs into practical solutions.
- Extensive experience developing algorithms for protein design, engineering, discovery, or sequence analysis.
- Demonstrated experience developing and applying AI/ML methods to proteins or other biological sequences.
Requirements
- Minimum of 5 years of industry experience with a PhD.
- Strong understanding of protein language models (PLMs) and protein sequence-structure-function relationships.
- A strong understanding of protein language models (PLMs) and their use in biological sequence design is required.
Nice to have
- Experience with antibody discovery, engineering, or characterization is highly preferred but not required.
- Experience with biopanning, display-based discovery, or other protein-selection platforms.
- Experience integrating protein sequence, NGS, and experimental assay data.
- Experience with generative protein design, property prediction, or candidate-ranking methods.
- About Twist Bioscience
- Twist Bioscience synthesizes genes from scratch, known as "writing" DNA.
- Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.
- Twist Bioscience Corporation is an Equal Opportunity Employer.
Compensation
- San Francisco Bay Area Pay Range
Benefits
- PhD in computational biology, bioinformatics, machine learning, computer science, protein science, or a related field.
Company info
- At Twist Bioscience, we work in service of people who are changing the world for the better.
- In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.
This listing is sourced directly from Twist Bioscience's careers page and normalized into a canonical job model.