Exel
Principal Scientist (Cell Line Development)
Alameda, CA · Principal
Sponsorship not specified$150k-$213kDetected 32 days ago
Data AnalysisProcess ImprovementMolecular BiologyResearchMass SpectrometryAnimal StudiesCommunicationCollaborationPublic Speaking
Stay score
odds of building a lasting career here
61Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role90
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70
Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
Personalize to your clock →Employer immigration record
from this employer's Department of Labor filings
Green-card filing pattern in this occupation
Context, not a finding about this posting: of this employer's 3 green-card filings in this occupation, 100% were for a worker who already held the job.
Files H-1B transfers
1 transfer filing in the last year, covering 1 worker. Median labor-condition decision: 9 days. An employer that already files transfers is one that can take over an existing H-1B.
Sourced from Department of Labor LCA, PERM and prevailing-wage disclosure data. Employer matching is by name, so figures may be split across an employer's legal entities. Absence of a filing means none appears in our copy of the data, not that none exists.
Community outcomes
No reports yet — be the first to help the next applicant.
About the role
- Every Exelixis employee is united in an ambitious cause: to launch innovative medicines that give patients, and their families hope for the future.
- In this pursuit, we know our employees are our most valuable asset.
- After operating in the challenging biotech sector for 25 years, we have a proven track record of resiliency in the face of adversity.
Responsibilities
- Design and execute experiments to develop CHO-based cell lines for biologic therapeutics moving into clinical development.
- Perform therapeutic CHO cell line development processes including transfection, single cell cloning, imaging analysis to document monoclonality, clone screening and progression, characterization, and cell banking and stability assessment of cell banks using state-of-the-art equipment
- Drive innovation through the development of improved expression vectors and genetic components, host cell line engineering and/or cell line development process optimization
Requirements
- It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.
- Bachelor's degree in related scientific discipline such as molecular biology, biochemistry, biology or microbiology and a minimum of eleven (11) years of experience in the biotechnology/pharmaceutical industry
- Master's degree in related scientific discipline such as molecular biology, biochemistry, biology or microbiology and a minimum of nine (9) years of experience in the biotechnology/pharmaceutical industry.
Nice to have
- The role is for an experienced incumbent who is eager, hands-on, detail-oriented, driven, self-motivated and experienced to contribute with minimal onboarding or training.
- The candidate must have demonstrated proficiency in molecular biology, vector construction and genetic elements that impact recombinant antibody/bispecific expression.
- The candidate must have experience with various stable CHO expression platforms to articulate pros and cons and recommend one suitable for developing manufacturing cell lines.
- The candidate must be well versed in transfection methodologies as well as screening and selection workflows.
- The candidate must have a deep understanding about regulatory requirements with respect to demonstrating monoclonality.
- Must have experience in culturing CHO cells in different formats such as shake flasks, spin tubes, and deep-well plate fed-batch processes.
- Experience in Ambr fed-batch processes is a plus.
Skills
- Equivalent combination of education and experience
- Solid understanding of mammalian protein/antibody expression, structure, and activity
- Ability to set goals with an understanding of priorities and impact to program, the department and the organization.
- Ability to thrive in a high-expectation, fast-moving environment
- Strong communication, organization, and documentation skills
- Prior experience with electronic laboratory notebook documentation and workflow management is a plus.
- Must have experience in single cell cloning and imaging technologies to prove monoclonality.
- Experience in running titer determination and standard downstream product quality assessments.
- Author and review cell line development reports, summaries and presentations
- Experience in analytical techniques such as HPLC, LC/MS, and/or CE is a plus.
- Familiarity with automation platforms and data analysis tools is a plus.
Compensation
- The base pay range for this position is $150,000 - $213,000 annually.
- The base pay range may take into account the candidate's geographic region, which will adjust the pay depending on the specific work location.
Benefits
- The base pay offered will take into account the candidate's geographic region, job-related knowledge, skills, experience and internal equity, among other factors.
- Employees are also eligible for a discretionary annual bonus program, or if field sales staff, a sales-based incentive plan.
- Comply with company health and safety policies and general laboratory practices.
Company info
- Exelixis employee is united in an ambitious cause:
- to launch innovative medicines that give patients, and their families hope for the future.
- The success of our lead product has provided a solid commercial foundation allowing us to reinvigorate our research efforts and grow our team in areas such as Drug Discovery, Clinical Development and Commercial.
- As we expand our global partnerships and further reinvest in R&D to help us discover the next breakthrough for difficult-to-treat cancers, we're seeking to add talented, dedicated employees to power our mission.
- Cancer is our cause.
- Make it yours, too.
- Significant effort designing complex experimental approaches to improve expression systems and workflows through innovation and implementation of new technology is also an important part of this role.
This listing is sourced directly from Exel's careers page and normalized into a canonical job model.