Exel

Principal Scientist (Cell Line Development)

Alameda, CA · Principal

Sponsorship not specified$150k-$213kDetected 12 days ago

Data AnalysisProcess ImprovementMolecular BiologyResearchMass SpectrometryAnimal StudiesCommunicationCollaborationPublic Speaking

About the role

Every Exelixis employee is united in an ambitious cause: to launch innovative medicines that give patients, and their families hope for the future.
In this pursuit, we know our employees are our most valuable asset.
After operating in the challenging biotech sector for 25 years, we have a proven track record of resiliency in the face of adversity.

Design and execute experiments to develop CHO-based cell lines for biologic therapeutics moving into clinical development.
Perform therapeutic CHO cell line development processes including transfection, single cell cloning, imaging analysis to document monoclonality, clone screening and progression, characterization, and cell banking and stability assessment of cell banks using state-of-the-art equipment
Drive innovation through the development of improved expression vectors and genetic components, host cell line engineering and/or cell line development process optimization
The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification.

Bachelor's degree in related scientific discipline such as molecular biology, biochemistry, biology or microbiology and a minimum of eleven (11) years of experience in the biotechnology/pharmaceutical industry
Master's degree in related scientific discipline such as molecular biology, biochemistry, biology or microbiology and a minimum of nine (9) years of experience in the biotechnology/pharmaceutical industry.
PhD degree in related scientific discipline such as molecular biology, biochemistry, biology or microbiology and a minimum of five (5) years of experience in the biotechnology/pharmaceutical industry.
It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

The role is for an experienced incumbent who is eager, hands-on, detail-oriented, driven, self-motivated and experienced to contribute with minimal onboarding or training.
The candidate must have demonstrated proficiency in molecular biology, vector construction and genetic elements that impact recombinant antibody/bispecific expression.
The candidate must have experience with various stable CHO expression platforms to articulate pros and cons and recommend one suitable for developing manufacturing cell lines.
The candidate must be well versed in transfection methodologies as well as screening and selection workflows.
The candidate must have a deep understanding about regulatory requirements with respect to demonstrating monoclonality.
Must have experience in culturing CHO cells in different formats such as shake flasks, spin tubes, and deep-well plate fed-batch processes.
Experience in Ambr fed-batch processes is a plus.

Solid understanding of mammalian protein/antibody expression, structure, and activity
Ability to set goals with an understanding of priorities and impact to program, the department and the organization.
Ability to thrive in a high-expectation, fast-moving environment
Strong communication, organization, and documentation skills
Prior experience with electronic laboratory notebook documentation and workflow management is a plus.
Equivalent combination of education and experience
Must have experience in single cell cloning and imaging technologies to prove monoclonality.
Experience in running titer determination and standard downstream product quality assessments.
Author and review cell line development reports, summaries and presentations
Experience in analytical techniques such as HPLC, LC/MS, and/or CE is a plus.
Familiarity with automation platforms and data analysis tools is a plus.

The base pay range for this position is $150,000 - $213,000 annually.
The base pay range may take into account the candidate's geographic region, which will adjust the pay depending on the specific work location.

The base pay offered will take into account the candidate's geographic region, job-related knowledge, skills, experience and internal equity, among other factors.
Employees are also eligible for a discretionary annual bonus program, or if field sales staff, a sales-based incentive plan.
Comply with company health and safety policies and general laboratory practices.

to launch innovative medicines that give patients, and their families hope for the future.
The success of our lead product has provided a solid commercial foundation allowing us to reinvigorate our research efforts and grow our team in areas such as Drug Discovery, Clinical Development and Commercial.
As we expand our global partnerships and further reinvest in R&D to help us discover the next breakthrough for difficult-to-treat cancers, we're seeking to add talented, dedicated employees to power our mission.
Cancer is our cause.
Make it yours, too.
Significant effort designing complex experimental approaches to improve expression systems and workflows through innovation and implementation of new technology is also an important part of this role.

If you have a disability and need an accommodation in relation to the application and/or recruitment process, please email us at: recruiting@exelixis.com.

This listing is sourced directly from Exel's careers page and normalized into a canonical job model.