Personalis, Inc
Sr. Software Engineer, Clinical Software
Fremont, CA · Senior · Full-time
Stay score
odds of building a lasting career here
Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
Personalize to your clock →H-1B wage level
the lottery is wage-weighted — each level is one more entry
$15,131 more — $165,131 — moves this role to Level II and 2 lottery entries. That figure is inside the range the employer already advertised.
Based on the DOL prevailing wage for this occupation and worksite, a base salary of $165,131 would place this position at wage Level II. That figure is within the posted range, and I'd like to target it. This role classifies under "Software Developers" for prevailing-wage purposes.
DOL prevailing wage, 2026-27 wage year · Software Developers (15-1252) · San Francisco-Oakland-Fremont, CA. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
Community outcomes
No reports yet — be the first to help the next applicant.
About the role
- Personalis is based in Fremont, California.
- This role is a key contributor to our engineering team, taking ownership of feature development for both existing systems and new cloud-based platforms.
- The hiring range for this position is $150,000 to $175,000 per year, which may factor in various geographic regions.
Responsibilities
- Design, develop, test, and maintain software systems and features supporting laboratory operations.
- Develop and optimize backend services and APIs using Python and/or Java.
- Implement solutions using a variety of database technologies, including relational and graph databases.
- Actively participate in code reviews, design discussions, and technical documentation to ensure quality and maintainability.
- Collaborate with cross-functional teams to translate business requirements into robust technical solutions.
- We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient.
- Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time.
- Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development.
- Opportunity to take ownership of significant features and projects from design to deployment.
Requirements
- B.S. degree in Computer Science, Engineering, or a related technical field.
- 5 years of professional software development experience.
- Strong proficiency in at least one programming language such as Python or Java.
- Solid experience with relational databases (e.g., PostgreSQL, MySQL) and developing REST APIs.
- Experience with version control systems (e.g., Github, Bitbucket) and CI/CD concepts.
- Excellent problem-solving skills and the ability to work independently on complex tasks.
- Experience with web frameworks like Flask or FastAPI.
- Familiarity with modern JavaScript frameworks (e.g., React, Angular, or Vue.js).
- Familiarity with containerization technologies (e.g., Docker).
- Deepen your expertise in AWS services and cloud architecture.
- Proven experience building and deploying applications on AWS.
- Preferred:
- Experience in the life sciences, healthcare, or another regulated industry.
- Exposure to graph databases or NoSQL technologies.
- What You'll Gain
Skills
- Monday, Tuesday, and Thursday
Compensation
- The hiring range for this position is $150,000 to $175,000 per year, which may factor in various geographic regions.
Company info
- At Personalis, we are transforming the active management of cancer through breakthrough personalized testing.
- As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations.
- Protecting Our Candidates: At Personalis, we value your security.
This listing is sourced directly from Personalis, Inc's careers page and normalized into a canonical job model.