Neurocrine Biosciences
Sr. Scientist, Mass Spectrometry & Biologics Characterization
US CA San Diego · Senior
Sponsorship not specified$131k-$179kDetected 3 days ago
Project ManagementFDA RegulatoryResearchMass SpectrometryAnimal StudiesCommunicationCollaborationProblem SolvingCritical Thinking
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odds of building a lasting career here
57Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role90
Entry-level history0
PERM / green-card track0
Lottery odds (Level III)83
Fits your clock70
Sponsors, but it's cap-subject — you still face the weighted lottery (~45% per draw at Level III). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
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Files H-1B transfers
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About the role
- Provide fit-for-purpose characterizations for various discovery-stage programs such as pre-engineering and active engineering efforts
- Execute sample preparation workflows, such as buffer exchange, immunoprecipitation, reduction and alkylation, enzymatic digestion
- Provides recommendations to improve process efficiency and research quality
Responsibilities
- Develop and implement advanced mass spectrometry methods applicable across modalities and development stages, with particular emphasis on native MS, top-down MS, and advanced structural characterization
- Support Lead Optimization production activities through high-throughput intact mass analysis of stable pools and clones, providing molecular identity and early semi-quantitative N-glycan profiling as additional data for cell-line selection.
- Perform manual and automated sample injections acquire LC-MS data, analyze data, draft report and document experiment in ELN, support stakeholders including discovery biology, protein engineering and lead optimization
- Manage sample receiving, testing and storage, maintain and track consumables including columns, buffer solutions, enzymes and chemicals
- Leverage literature, ICH/Regulatory guidance, and practical experience to perform this work and collaborate on CMC analytical development strategies
- Our dynamic team is seeking a motivated, collaborative, and experienced Senior Scientist to support biologics characterization for analytical development team.
- The qualified individual will work closely with team members to design, develop, and execute assays to deliver robust and high-quality data to drive decision-making.
Requirements
- BS/BA degree in chemistry or closely related field and 12+ years of pharmaceutical industry experience, focusing on separation method development OR
- PhD in chemistry or closely related field and 4+ years of applicable experience
- Working knowledge of protein chemistry, amino acid composition, primary structure, post-translational modifications, higher-order structure and protein-protein interactions
- Knowledge of cross-functional understanding related to drug development
- Ability to meet deadlines
Nice to have
- MS/MA degree in chemistry or closely related field preferred and 10+ years of pharmaceutical industry experience noted above OR
Compensation
- The annual base salary we reasonably expect to pay is $130,800.00-$179,000.00.
Company info
- Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. ( *in collaboration with AbbVie )
- About the Role:
- Our dynamic team is seeking a motivated, collaborative, and experienced Senior Scientist to support biologics characterization for analytical development team. The qualified individual will work closely with team members to design, develop, and execute assays to deliver robust and high-quality data to drive decision-making. The position requires a dedicated mass spectrometry expertise supporting modality-agnostic characterization, developability assessment, and advanced method development from preclinical research through early development. Along with that, the position requires excellent scientific, technical and laboratory skills, strong organizational and communications skills, and enthusiasm for contributing to a fast-paced organization focused on discoveries of novel and differentiated therapeutic candidates. _
- Your Contributions (include, but are not limited to):
- Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs.
- We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders.
- The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas.
- For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions.
- We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science.
- For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. ( *in collaboration with AbbVie )
- Biosciences is a leading biopharmaceutical company with a simple purpose:
- to relieve suffering for people with great needs.
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