Parabilis Medicines

Vice President, Biochemistry and Head of Early Discovery Projects

Cambridge · Exec · Full-time

Sponsorship not specified$310k-$340kDetected 33 days ago

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About the role

The company has pioneered a new class of alpha-helical peptides - Helicons™ - capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines.
Zolucatetide is being evaluated in the clinic across multiple Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications.
Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact.

Lead our early discovery portfolio (currently ramping up to 6 concurrent projects), providing scientific direction and support to teams and their leaders.
Guide projects from target evaluation and hit discovery through hit-to-lead and successful transition into late discovery, partnering with project teams to establish scientific strategy and execution plans, evaluate key scientific inflection points, recommend strategic pivots when needed, and drive critical go/no-go decisions.
Collaborate closely with the display screening, AI/CDD, biology, synthesis, design, platform, structural biology, and other groups involved in early projects.
Directly manage our biochemistry and biophysics team (currently 5 full-time team members, with one additional new opening).
Mentor and develop early discovery project leaders, fostering scientific growth, strategic thinking, and strong program leadership capabilities across the organization while helping build the next generation of discovery leadership within Parabilis.
Serve as primary scientific liaison to collaboration partners, working closely with BD/Alliance Management.
Ability to recruit and develop scientific talent, and to mentor and grow project leaders.
Excellent scientific communication skills, and ability to represent portfolio credibly to senior leadership, partners, and external stakeholders.
30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com

PhD in biochemistry, chemical biology, or related field, with 15+ years of drug discovery experience in industry.
Experience leading or co-leading multiple cross-functional discovery projects.
Deep expertise in protein biochemistry and biochemical/biophysical assays (e.g., SPR, TR-FRET, HDX, ITC, structural biology), and familiarity with cell-based screening assays.
Ability to think strategically about portfolio-level decision-making, including stage-gate frameworks, go/no-go criteria, and resource prioritization across multiple concurrent efforts.

Experience leading or contributing to external partnerships (academic, biotech, or pharma alliances) is a plus.

The base salary range for this position is $310,000-$340,000, depending on experience, qualifications, and internal practices.
Parabilis's total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees' overall well-being.

The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

Significant experience working as part of drug discovery project teams and driving candidates to IND and clinic, preferably in small molecule or peptide modalities against intracellular targets.
We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences.

This listing is sourced directly from Parabilis Medicines's careers page and normalized into a canonical job model.