Generate Biomedicines

Generate Biomedicines

Scientist I, Functional Bioassay & High-Throughput Screening

Somerville, MA

Sponsorship not specified$80k-$90kDetected 9 days ago
Machine LearningData ScienceA/B TestingRecruitingPharmacologyFlow CytometryMolecular BiologyCell CultureResearchProtein AnalysisAnimal StudiesLeadershipCommunicationCollaborationAdaptabilityOrganizational Skills

About the role

  • Key areas of focus may include ion channel, GPCR, ADC-related functional HTS assays, and other cell-based or biochemical screening platforms as portfolio needs evolve.

Responsibilities

  • The Functional Bioassay team is seeking a Scientist I, Functional Bioassay / High-Throughput Screening to support the development, optimization, and execution of functional assays across Generate's growing portfolio of therapeutic programs.
  • Design, optimize, and implement HTS-compatible biochemical and cell-based assays, with appropriate integration of automation.
  • Clearly communicate findings to program teams to support AI/ML-enabled design cycles, program prioritization, and iterative therapeutic optimization.
  • Support multiple therapeutic programs as a functional assay contributor, with potential focus areas including ion channel, GPCR, and ADC-related assays.
  • Maintain accurate, timely, and well-organized records in electronic laboratory notebooks and other data systems.
  • Collaborate with colleagues across Functional Bioassay, Automation, Biology, Protein Sciences, Data Science, and program teams to ensure experiments are well coordinated and aligned with project needs.

Requirements

  • Hands-on experience with cell-based, biochemical, or functional assays in an academic, biotech, pharmaceutical, or related research setting.
  • Experience with ELISA, HTRF, AlphaLISA, luminescence/fluorescence assays, flow cytometry, or similar assay technologies.
  • Familiarity with high-throughput or medium-throughput screening workflows, including multiwell plate formats.
  • Ability to follow established protocols while recognizing when assay performance, data quality, or experimental results require troubleshooting.
  • Ability to analyze and present data clearly using tools such as GraphPad Prism, ScreenWorks, Harmony, iQue Forecyt, Spotfire, or similar platforms.

Nice to have

  • Experience with ion channel assays or related functional readouts, such as electrophysiology-adjacent workflows, membrane potential assays, or thallium flux assays.
  • Experience with GPCR assays, including reporter assays, calcium flux assays, cAMP assays, beta-arrestin assays, or other pathway-based functional assays.
  • Experience with ADC, image-based internalization, targeted protein degradation, immune cell, or cytotoxicity assay formats.
  • Experience working with primary cells, engineered cell lines, or stable cell line generation.
  • Experience with lab automation systems, such as HighRes, Beckman Biomek i5/i7, Hamilton, EL406, Multidrop, or equivalent liquid handling platforms.
  • Experience working in a biotech or pharmaceutical research environment and/or interest in applying functional biology to AI/ML-enabled therapeutic discovery.
  • About Generate Biomedicines
  • Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates.

Skills

  • The scientist will help advance platform-wide innovation in assay execution, data quality, automation onboarding, and workflow scalability.
  • Execute plate-based HTS campaigns, analyze results, and interpret complex experimental datasets.

Compensation

  • The base salary range provided reflects our current estimate of what we anticipate paying for this position.
  • Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics.
  • In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.
  • Per Year Salary Range
  • $102,000 - $143,000 USD

Company info

  • Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates.

Visa & Work Authorization

  • al employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status
Apply directly at Generate Biomedicines →Create a free account for alerts like thisView Generate Biomedicines immigration profile

This listing is sourced directly from Generate Biomedicines's careers page and normalized into a canonical job model.