City Therapeutics

Associate Director, Toxicology (Nonclinical Safety Evaluation)

Cambridge, Massachusetts, United States · Director

Sponsorship not specified$174k-$196kDetected 35 days ago

PharmacologyFDA RegulatoryExperimental DesignCommunicationCollaborationOrganizational SkillsRegulatory Affairs

About the role

We're seeking an Associate Director, Nonclinical Safety Evaluation (NSE) who will play a pivotal role in overseeing and critically evaluating nonclinical safety studies across City's RNAi therapeutic programs.
You will be responsible for providing scientific oversight of outsourced nonclinical safety studies, reviewing and interpreting results, and ensuring that findings are placed in the appropriate biological and development context.

We collaborate intensely, with candor and optimism, taking ownership and celebrating the journey together.
In Person, By Design
We believe in developing talent, and that happens best when we're together.
We believe diverse teams drive better science.

Ability to assess study quality, identify issues early, and communicate risks and recommendations clearly to cross-functional stakeholders.

Serve as the primary scientific reviewer for outsourced nonclinical safety studies, critically evaluating protocols, amendments, reports, and raw or interpreted data to ensure rigor, clarity, and appropriate conclusions.
Identify data gaps, inconsistencies, or study conduct issues, and work with internal and external teams to resolve them efficiently and scientifically.
Participate actively in cross-functional team meetings to communicate study progress, interpret findings, and provide nonclinical safety input to broader program discussions.
Contribute to the planning and monitoring of nonclinical safety studies required to support candidate progression and regulatory submissions.
Represent Nonclinical Safety Evaluation in cross-functional discussions, clearly communicating study outcomes, risks, and recommendations.
Stay current on evolving toxicology methods, nonclinical safety expectations, and regulatory guidance relevant to RNAi and oligonucleotide therapeutics.
Strong experience overseeing outsourced nonclinical safety studies and critically reviewing protocols, data, and final reports.

The base salary range provided reflects our current estimate of what we anticipate paying for this position.
Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics.
In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.
Pay range is $174,000 to $196,000
Why You'll Love Working Here
At City, you'll be part of a team that's as ambitious as it is collaborative. We're building an organization that is united by our values:

Learning moves faster in person.
When individual needs arise, we're flexible and supportive and work together to balance home life with life at City.

Face time matters.
Building an enduring biotech company is about people, science, and strategy.
Working side by side sharpens ideas, accelerates feedback, and fuels innovation for patients.
At City, we believe that science and culture thrive together, and that happens best in person.
We welcome applicants from all backgrounds and experiences who share our mission to bring transformative RNAi medicines to patients.

This listing is sourced directly from City Therapeutics's careers page and normalized into a canonical job model.