Raven
Raven StealthCo - Scientist, Conjugation Chemistry
Boston, MA
Sponsorship not specified$120k-$170kDetected 7 days ago
Intellectual PropertyClinical TrialsResearchMass SpectrometryAnimal StudiesAnimal ModelsLeadershipAdaptabilityOrganizational Skills
About the role
- The Scientist, Conjugation Chemistry will report directly to the Director of Oligonucleotide and Conjugation Chemistry and will interface frequently with members of the delivery group and cross-functional teams to advance oligonucleotide therapeutic programs.
- This individual will help define and execute the chemical strategy to produce oligonucleotide conjugates in an efficient and timely manner.
- As a lab-based role, this person will assist in the implementation and use of scientific and analytical equipment to yield high-quality conjugate materials.
Responsibilities
- They have brought hundreds of therapeutics into development, managed hospital systems, optimized clinical trials and navigated payor and regulatory systems to deliver patient impact - and they are ready to work with you.
- Define and implement reproducible technical protocols to develop oligonucleotide conjugates for biological evaluation in our targeted delivery platform
- Develop conjugation strategies (cysteine, lysine, glycan, site-specific, etc.) to yield stable and well-characterized oligonucleotide conjugates
- Design and incorporate linker chemistries for oligonucleotide conjugates to optimize PKPD
- Assist in internal lab build, procuring and utilizing equipment to enable conjugation and purification of antibody/peptide-oligonucleotide conjugates
- Work hand-in-hand with protein engineers and biologists to ensure timely and adequate preparation of oligonucleotide conjugates for biological evaluation as well as contribute to the design of in vitro and in vivo studies
- Assist analytical scientists in developing methods (HPLC, MS, etc.) to characterize oligonucleotide conjugates
Requirements
- The Scientist, Conjugation Chemistry should be a doer with the ability to generate high-quality conjugate materials efficiently and effectively, while contributing to the interpretation of complex scientific data.
- Imperative that this individual be an effective communicator and proven team-player, with the ability to operate independently in a laboratory setting
- The Scientist, Conjugation Chemistry must be highly organized, thoughtful, and bring sound judgement and technical decision-making abilities.
Nice to have
- Experience working with oligonucleotide-based therapeutic modalities such as siRNAs and ASOs is a plus
Skills
- Final compensation will depend on factors like experience, skills, and location.
Compensation
- The base salary range reflects our good faith estimate at the time of posting.
Company info
- Contribute to intellectual property around oligonucleotide-conjugates for the company
- At a personal level, we are seeking an individual who is highly collaborative, intellectually curious, driven, trustworthy, humble, and who brings an adaptable and flexible working style.
- The company is creating a culture of highly engaged colleagues who put the team and the science above the self and operate with a sense of urgency.
- From an educational perspective, we are seeking an individual with a Ph.D. and/or BS/MS in a relevant discipline such as chemistry or protein engineering.
- This person will be based on-site at the company's headquarters in Cambridge, MA.
This listing is sourced directly from Raven's careers page and normalized into a canonical job model.