Flagshippioneeringinc
Principal Scientist, Agentic Systems for Pipeline Strategy
Cambridge, MA USA · Principal
Sponsorship not specifiedDetected 7 days ago
Machine LearningLLMsAgentic AIBusiness DevelopmentResearchAnimal Studies
About the role
- The successful candidate brings deep clinical and commercial pipeline strategy expertise and a real working relationship with frontier AI; PI brings the engineering depth and research environment to take that AI work to the next level.
- Their work will ultimatly impact the whole Flagship ecosystem.
Responsibilities
- Serve as PI's in-house subject matter expert on clinical and commercial pipeline strategy, embedding domain judgment directly into the AI capabilities PI develops.
- Own the "legitimate patient need" problem end-to-end: define what it means for an agentic tool to identify and value a real, underserved patient need, what a product that addresses it looks like, and build the evaluations, ground-truth sets, and feedback loops that make agent outputs trustworthy enough to inform pipeline decisions.
- Prototype agentic capabilities directly: building prompts, tools, and orchestration logic, and partnering with engineering to harden systems for production use.
- Collaborate closely with business and strategy analysts across the ecosystem translating their strategic questions into agent specifications and translating emerging agent capabilities back into strategic possibilities.
- We are seeking a Principal Scientist to join Pioneering Intelligence (PI), a Flagship initiative dedicated to developing AI/ML-powered platforms for transformative applications in life sciences.
Requirements
- Significant translational medicine experience, shepherding post-development candidate assets through IND and Phase 1, with routine engagement across late-stage preclinical, CMC, regulatory, and clinical functions.
- Familiarity with industry pipeline and competitive intelligence databases (e.g., Clarivate Cortellis, EvaluatePharma, Citeline, GlobalData).
- Comfort reading and writing code well enough to prototype agentic workflows, working alongside PI's engineers initially and growing toward independent prototyping.
- Production-grade engineering is not required.
- PhD or MD (or equivalent doctoral-level training) in a life science, medical, or related discipline.
- Deep domain expertise in clinical and commercial pipeline strategy, drug development, or therapeutic area strategy, with a track record of personally making or directly influencing portfolio and indication-selection decisions.
- Strong intuition for what constitutes a legitimate patient need versus a commercially convenient framing, and a history of pushing organizations toward the former.
- Meaningful, sustained use of frontier LLMs (e.g., Claude) in your own work. You've moved well past casual chat into structured prompting, tool use, and decomposition of complex tasks, and you want your next role to push that practice further.
- Comfort reading and writing code well enough to prototype agentic workflows, working alongside PI's engineers initially and growing toward independent prototyping. Production-grade engineering is not required.
- Principal-level operating
Apply directly at Flagshippioneeringinc →Create a free account for alerts like thisView Flagshippioneeringinc immigration profile
This listing is sourced directly from Flagshippioneeringinc's careers page and normalized into a canonical job model.