Generate Biomedicines

Project Team Lead (PTL, cardio-renal-metabolic)

Somerville, MA · Director

Sponsorship not specified$177k-$260kDetected 56 days ago

Machine LearningLLMsA/B TestingRecruitingResearchLab ResearchExperimental DesignAnimal StudiesLeadershipCommunicationCollaboration

About the role

This is a Director-level role with broad matrix leadership responsibilities and significant influence across research, platform, translational, and portfolio decisions.
This role is accountable for the overall success of assigned programs, including project-level decisions, go or no-go recommendations, and clear communication of program strategy, risks, and tradeoffs to senior leadership.
Be accountable for the progress of assigned programs, including overall scientific direction, team effectiveness, execution quality, and readiness for key stage-gate decisions.

Responsibilities

Generate:Biomedicines is seeking an experienced Project Team Lead (PTL) to lead complex, cross-functional scientific teams, advance multiple programs from concept and early discovery through preclinical proof-of-concept, and contribute to translational and early development planning.
The PTL combines deep scientific judgment, strategic program leadership, and operational rigor to shape integrated research plans, drive execution, and ensure programs progress efficiently through key decision points.
Working closely with the Portfolio Lead, project managers, and functional leaders, the PTL will facilitate cross-functional discussions, make recommendations, and own final project decisions within the team structure.
The PTL will also represent programs in governance forums, shape portfolio strategy, and drive alignment across functions in ways that support broader company priorities.
Develop and maintain integrated program strategies and plans that align scientific objectives, timing, dependencies, resourcing, budgets, critical path activities, and decision points.
Facilitate team discussions, synthesize diverse inputs, make clear recommendations, and drive timely project team decisions and go or no-go recommendations.
Partner with the Portfolio Lead and senior functional leaders to shape portfolio strategy, refine program direction as data emerge, and ensure execution remains aligned with company priorities.
Drive execution across wet lab, computational, platform, and translational workstreams, ensuring scientific rigor, strong documentation, reproducibility, and high-quality data packages.
Develop program resource plans and budget assumptions, and partner with the Portfolio Lead and functional leaders on final resource and budget decisions.
Anticipate and resolve risks, gaps, and cross-functional dependencies to maintain program momentum in a fast-moving environment.

Requirements

10+ years of experience leading complex cross-functional research or program teams in biotech, pharma, academia, or a related scientific environment, with scope consistent with a Director-level role.

Nice to have

Experience working on protein therapeutics and related modalities in discovery or development settings, including peptides and conjugate-based approaches.
Experience with target selection and target validation, including assessment of biological rationale, tractability, translational relevance, and overall fit with portfolio strategy.
Understanding of translational strategy, including PK/PD considerations and the role of translational studies in guiding program decisions.
Familiarity with IND-enabling studies and early clinical development.
Who Will Love This Job:
A biomedical scienstist who loves hunting for novel targets and turning early scientific ideas into well-defined therapeutic opportunities.
A scientifically grounded leader who enjoys owning complex programs and making high-stakes decisions with incomplete information.
A person who enjoys connecting biology, platform capabilities, translational thinking, and portfolio priorities to move the most promising ideas forward.

Compensation

The base salary range provided reflects our current estimate of what we anticipate paying for this position.
Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics.
In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.
Per Year Salary Range
$177,000 - $260,000 USD

Company info

Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates.
The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company's internal Talent Acquisition team.
Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

Visa & Work Authorization

al employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status

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