Nurix Therapeutics

Senior Scientist, Antibody Conjugation

Brisbane, CA · Senior

Sponsorship not specified$155k-$180kDetected 3 days ago

PharmacologyMass SpectrometryAnimal StudiesLeadershipProblem Solving

About the role

We are growing the team with a hands-on antibody conjugation scientist who will build this capability from the ground up by developing and validating bioconjugation chemistries that are reproducible at bench scale, sufficiently robust for transfer to automated higher-throughput synthesis workflows, and scalable for preparation campaigns supporting advanced in vivo and translational studies.
This is a lab-based role for someone who wants to build a new technical capability inside an established, highly collaborative discovery organization and partner closely with medicinal chemistry, analytical chemistry, computational chemistry, protein biochemistry, and automation to move candidates from bench to study-ready material.

Develop and optimize antibody bioconjugation methods for attaching degrader payloads and linkers to antibodies.
Design conjugation chemistry with an eye toward automation: define protocols, reagent ratios, and process parameters in a form that can be transferred to and run reliably on liquid-handling platforms.
train and support automation-team colleagues in executing conjugation workflows independently.
Collaborate cross-functionally with medicinal chemists (linker/payload design), computational chemists (site selection, modeling), and external CROs/CDMOs as needed.
Results-oriented: you drive a method from first attempt to a robust, transferable protocol, and you personally deliver material when a study needs it.
Write clear SOPs and technical reports; train and support automation-team colleagues in executing conjugation workflows independently.

Experience purifying and characterizing conjugates: FPLC/AKTA, TFF, SEC, IEX, RP-HPLC/UPLC, HIC, and LC-MS-based DAR/identity analysis.
Direct, hands-on experience with antibody/protein bioconjugation chemistry: NHS ester and maleimide coupling, click chemistry (CuAAC/SPAAC/IEDDA), engineered-cysteine or glycan/enzymatic site-specific conjugation, or unnatural-amino-acid approaches.
Experience preparing protocols for automated or semi-automated execution (e.g., liquid handlers such as Hamilton or Tecan) is a strong plus, though the successful candidate may also learn this in partnership with our automation team.
Why This Role
You'll be the founding technical expert for antibody conjugation at Nurix, shaping both the science and how it's automated and scaled - with direct visibility to program leadership and a fast path from method development to real studies
Salary Range: 155K - 180K plus bonus and equity
Fit with Nurix Culture and Values
Strong team orientation
highly collaborative
Solutions and results-oriented focus
Hands-on approach

Comfortable owning a technical area with real autonomy in a growing capability area.
PhD in chemistry, biochemistry, chemical biology, or a related field preferred
MS or BS with substantial (8+ for BS/MS) hands-on industry bioconjugation experience will also be considered.
Strong record of practical problem-solving in the lab, with the judgment to know when a result is study-ready versus needs more optimization

We are an Equal Opportunity Employer offering a competitive salary and benefits package.

This listing is sourced directly from Nurix Therapeutics's careers page and normalized into a canonical job model.