Earli Inc.
Scientist/Sr Scientist, Protein Engineering
Redwood City, CA · Senior
Sponsorship not specified$110k-$145kDetected 20 days ago
ExpressComputer VisionIntellectual PropertyFDA RegulatoryPCRqPCRCRISPRFlow CytometryMolecular BiologyResearchExperimental DesignProtein AnalysisWestern BlottingAnimal StudiesLeadershipCommunicationCollaborationPublic Speaking
About the role
- Earli is seeking a highly motivated and scientifically rigorous Scientist/Senior Scientist to join our Therapeutics Group.
- You will work at the intersection of protein science and translational immunology, partnering closely with the broader Therapeutics and Platform teams to advance Earli's pipeline from early-stage discovery through preclinical proof-of-concept.
- This position reports to the Head of Therapeutics.
Responsibilities
- Cancer cells become their own drug factories, enabling localized immune activation, even in cold tumors.
- Molecular/Protein Design & Engineering
- Stay current with the scientific literature on protein therapeutics, bispecific engager biology, cytokine engineering, and relevant tumor immunology to inform design decisions.
- Develop and execute medium-throughput transient mammalian expression workflows (HEK293, CHO, or equivalent) to produce protein candidates for functional evaluation.
- Establish quality criteria to prioritize candidates for to functional assays; maintain comprehensive records of expression and purification outcomes.
- Design, develop, and execute functional assays in relevant cancer cell lines and primary human immune cells (PBMCs, T cells, NK cells, monocytes/macrophages) to evaluate candidate activity, potency, and selectivity.
- Design and execute tumor microenvironment (TME)-relevant in vitro model systems, including co-culture platforms, to assess immunological mechanism of action (MoA).
- Contribute original scientific thinking to project strategy, experimental design, and data interpretation; present findings to internal teams and leadership clearly and compellingly.
- Collaborate cross-functionally with Platform Biology, Delivery, and Computational teams to integrate protein therapeutics within Earli's cancer-activated gene expression system.
- Proactively identify scientific risks and propose mitigation strategies; drive projects forward with appropriate urgency in a fast-paced startup environment.
Requirements
- You work well in a fast-paced and extremely focused startup environment
- You are not only smart, but clever and constantly think outside the box
- You are able to make logical decisions in an instant when there is little time to evaluate
- You are a natural communicator and relationship builder
- You have the ability to multi-task in a serious way, with an extreme attention to detail
- You become a representative of the core DNA of the company through who you are
Skills
- Track record of generating high-quality, reproducible data and clear scientific communication in presentations and written reports.
- Ability to handle multiple projects simultaneously and meet aggressive project timelines.
- Exceptional verbal communication and scientific writing.
- Industry experience in biotherapeutics discovery, particularly in oncology.
- Familiarity with tumor microenvironment biology and ex vivo TME modeling approaches.
- Experience with high-throughput or automated expression/assay platforms.
- Experience with viral and non-viral gene delivery methods (lentivirus, AAV, mRNA, LNP) for cell line engineering or functional studies.
Compensation
- The anticipated base salary for this position is $110,000-$145,000 per year.
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