Shasqi

Vice President of Translational Sciences

United States · Exec

No sponsorship$30k-$325kDetected 15 days ago

PharmacologyFDA RegulatoryBioinformaticsScientific WritingResearchAnimal StudiesAnimal ModelsLeadershipCommunicationCollaborationWriting

About the role

Accountable for the translational development strategy for pipeline assets from drug candidate through IND submission and Phase 1 entry
Characterize drug mechanisms of action and resistance to inform clinical hypotheses, patient selection, and combination strategies
Ensure preclinical-to-clinical bridging is scientifically rigorous and clearly communicated

Are mission driven and eager to do the best work of your career, developing novel therapies that will transform cancer treatment.
Willing to collaborate, debate, commit to decisions clearly, and revisit when evidence demands it.
Support translational hypotheses and biomarker strategies that connect preclinical biology to clinical endpoints
Support targeted patient stratification and enrichment strategies that inform clinical trial design and improve probability of success
Identify and prioritize experiments, models, and data packages needed to support regulatory filings and clinical decision-making
Partner with research and clinical leadership to align translational milestones with overall program strategy
Collaborate closely with Research (animal models, PK/PD, efficacy), Clinical Development, Clinical Operations, and CMC to ensure translational readiness at each program gate
Support clinical protocol development by providing translational rationale for dosing, scheduling, patient selection, and biomarker collection
Contribute to the design and interpretation of early clinical data to inform go/no-go decisions and Phase 2 design
Backed by leading biotech investors, we are building a pipeline of first-in-class therapies that are designed to overcome the limitations of ADCs increasing efficacy and limiting toxicities.

Deep understanding of IND-enabling studies and the preclinical data packages required by the FDA and other regulatory agencies.
Hands-on experience with PK/PD, biomarker strategy, and dose selection for oncology programs.
Ability to work at the bench-to-bedside interface in a small, fast-moving team.
Must be authorized to work in the United States.

Experience with solid tumor indications.
Prior experience at a company transitioning from preclinical to clinical stage.
Experience collaborating with bioinformatics or computational biology teams on biomarker discovery, patient stratification, or translational data analysis.
We move quickly and operate with a high level of ownership and accountability.
Core collaboration window: 9:00am-3:00pm Pacific Time.
You are expected to be available during this time for meetings and real-time collaboration.
Async + sync balance: Outside of core hours, we work asynchronously, but timely communication and follow-through are expected.
Meetings: You should be comfortable joining video calls, sharing availability on calendar and actively participating during core hours.

The anticipated base salary range for this role is $300,00 - $325,000 USD, plus annual performance bonus and meaningful equity participation.
Final compensation will depend on location, experience, skills, education, and internal equity.
Competitive base salary as part of a broader total rewards package.

The anticipated base salary range for this role is $300,00 - $325,000 USD, plus annual performance bonus and meaningful equity participation.
medical, dental, vision, 401(k), short- and long-term disability.
Flexible PTO and a WFH stipend to support remote work.
Final compensation will depend on location, experience, skills, education, and internal equity.

We move fast because speed matters to cancer patients.
We aim to communicate openly and challenge ideas regardless of job title.
We are bold, take risks, and push boundaries being led by science.
Shasqi is a biotech company advancing a new class of targeted cancer therapies, built on Nobel prize-winning technology called click chemistry.
You can learn more about our company at www.shasqi.com http://www.shasqi.com
At this time, Shasqi is not partnering with external recruiting agencies.
We kindly ask that agencies refrain from contacting us regarding this role.
Shasqi is an Equal Opportunity Employer.
We are committed to creating a diverse and inclusive workplace and do not discriminate on the basis of any protected characteristic under applicable law.
We are not currently sponsoring visas.
Included as part of total compensation.

This listing is sourced directly from Shasqi's careers page and normalized into a canonical job model.