Korro Bio

Korro Bio

Senior Scientist, Computational Biology

60 First St, Cambridge, MA 02141 · Senior

Sponsorship not specified$150k-$200kDetected 75 days ago
PythonGitAWSDockerscikit-learnPandasNumPyData AnalysisData ScienceStatisticsPharmacologyBioinformaticsNGSResearchAnimal StudiesCommunicationPublic SpeakingGeneralized Linear Models

About the role

  • We are seeking an experienced and versatile Senior Scientist, Computational Biology to join our Data Science team and contribute across the breadth of Korro's research and translational programs.
  • This is a hands-on role suited to someone who has already proven themselves in a biotech or pharma environment and who thrives in a small, fast-moving organization where program needs evolve quickly.

Responsibilities

  • Drive computational biology analyses across Korro's research pipeline, including target validation, mechanism-of-action studies, and characterization of RNA editing activity in preclinical models.
  • Design, execute, and interpret NGS-based experiments (RNA-seq, variant calling, targeted amplicon sequencing) in support of oligonucleotide design, screening, and pharmacology workstreams.
  • Partner with platform biology, chemistry, and pharmacology teams to translate experimental questions into rigorous analytical workflows and to communicate results in a form that informs program decisions.
  • Develop and maintain reproducible analysis pipelines in R and/or Python, leveraging existing Data Science infrastructure (Posit Connect, MLflow, containerized environments, AWS).
  • Contribute analytical support to the preclinical-to-clinical translational handoff for our GalNAc-conjugated programs, including PK/PD characterization and biomarker analysis as programs mature.
  • Collaborate with cross-functional stakeholders to scope new analyses, set realistic timelines, and deliver results that are technically sound and decision-ready.
  • The successful candidate will operate as an analytical generalist - comfortable moving between target validation, NGS/omics analysis, assay analytics, and translational support for our oligonucleotide therapeutics pipeline.
  • Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform.
  • Korro is generating a portfolio of differentiated programs that are designed to harness the body's natural RNA editing process to effect a precise yet transient single base edit.

Requirements

  • Ph.D. in Computational Biology, Bioinformatics, Genomics, Computational Chemistry, or a related quantitative discipline, with 3+ years of post-PhD experience in a biotech or pharmaceutical industry setting.
  • Strong scientific programming in R and/or Python, with proficiency in standard biological data analysis libraries (Bioconductor, tidyverse, pandas, numpy, scikit-learn, etc.).
  • Familiarity with oligonucleotide or RNA-based therapeutics - including chemical modifications, delivery modalities (GalNAc, LNP), and the analytical considerations specific to ASOs, siRNAs, or related modalities.
  • Comfort working with messy, real-world experimental data and collaborating directly with bench scientists to refine analytical questions.
  • Excellent written and oral communication skills, including the ability to translate technical results for non-computational stakeholders.

Nice to have

  • Experience analyzing clinical or translational data - Phase 1 PK/PD, biomarker time-courses, or exposure-response analyses - is a strong plus.
  • Familiarity with hepatology, metabolic disease, or other indications relevant to GalNAc-conjugated oligonucleotide therapeutics.
  • Experience with cloud-based analytical infrastructure (AWS), containerized workflows (Docker), and reproducible reporting tools (Posit Connect, Quarto, R Markdown).
  • Prior contribution to IND-enabling packages or regulatory submissions.
  • Peer-reviewed publications in computational biology, genomics, or therapeutic pharmacology.

Compensation

  • Benefits: Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending acc

Benefits

  • We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases.
  • Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.

Company info

  • We are collaborative and united by a common mission.
  • Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization.
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