Sanofi Pasteur Inc.
Senior Associate Scientist
Waltham, MA · Senior
Sponsorship not specifiedDetected 1 day ago
ResearchLab ResearchMass SpectrometryAnimal StudiesCommunicationMentoringPublic SpeakingFermentation
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Lottery odds40
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About the role
- Join the team protecting half a billion lives every year with next-gen science, mRNA innovation, and AI-driven breakthroughs.
- In Vaccines, you'll help advance prevention on a global scale - and shape the future of immunization.
- About Sanofi: We're an R&D-driven, AI-powered biopharma company committed to improving people's lives and delivering compelling growth.
Responsibilities
- Evaluate, and implement purification technology and optimize existing techniques and workflows.
- Support the execution and optimization of plasmid DNA purification, problem solving.
- Design and execute decision-quality research; prepare/draft SOPs, technical reports, batch record, and presentations to management and other stakeholders.
Requirements
- Bachelor's OR Master's degree in Biotechnology, Chemistry, Chemical Engineering, Biomedical Engineering, or related scientific field
- Bachelor's degree holders: Minimum 3+ years of relevant industry experience in pharma, biotech, or laboratory settings
- Master's degree holders: Minimum 1+ year of relevant industry experience in pharma, biotech, or laboratory settings
- Hands-on experience with HPLC (High-Performance Liquid Chromatography) operations
Nice to have
- Hands-on experience in small- and large-scale plasmid DNA extraction and purification methodologies including alkali lysis, chromatography separation (anion exchange, hydrophobic interaction) and buffer exchange methods
- Familiar with Cytiva AKTA Pilot and Repligen TFF system (K2Ri and KMPi)
- Familiar with Sartorius PATfix system
- Prepare buffers for purification process
- Familiar with equipment setup, process troubleshooting and maintenance and experience in GLP environment is advantageous
- Works collaboratively within group for improved operational excellence as well as within interdisciplinary teams
- Desire to work in a team-first, fast-paced environment, learn new technologies and skills, and to efficiently solve problems
- Excellent organizational and communication skills
Compensation
- All compensation will be determined commensurate with demonstrated experience.
- Execute ~20 batches per year.
Benefits
- Employees may be eligible to participate in Company employee benefit programs.
- Additional benefits information can be found through the LINK.
Company info
- We are seeking a highly motivated and scientifically rigorous individual to join the Plasmid Production Pilot team.
- You will focus on execution and scale-up of a robust pDNA production process focusing on bacterial cell lysis, supercoiled plasmid DNA linearization, and purification for preclinical linearized plasmid DNA production, with the ultimate goal of transferring at scale methods to either the internal or external manufacturing team for mRNA drug substance with applications towards vaccine development.
- We're an R&D-driven, AI-powered biopharma company committed to improving people's lives and delivering compelling growth.
- Our deep understanding of the immune system - and innovative pipeline - enables us to invent medicines and vaccines that treat and protect millions of people around the world.
- Together, we chase the miracles of science to improve people's lives.
Visa & Work Authorization
- ual opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity
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