Insmed
Senior Scientist, Analytical Development (Large Molecule)
Research Development Lab - New Jersey · Senior · Full-time
Sponsorship not specified$127k-$166kDetected 71 days ago
ExcelHRPCRMass SpectrometryProtein AnalysisAnimal StudiesLeadershipCommunicationCollaborationMentoringOrganizational SkillsMicrosoft OfficeGxP
About the role
- We're looking for a Senior Scientist, Analytical Development (Large Molecule) on the Analytical Development team to help us expand what's possible for patients with serious diseases.
- Reporting to the Senior Manager, Large Molecule Analytical Development, you'll be responsible for managing the internal analytical laboratory and overseeing analytical activities conducted at CROs/CDMOs.
- Hands on experience and deep understanding of techniques like Peptide mapping, HPLC/UPLC (IEX, SE, RP), SEC-MALS, DLS, DSC, CD & CE-SDS along with impurity assays for HCP, residual Protein A, residual host cell DNA, Bioburden and Endotoxin detection.
Responsibilities
- In this role, you'll have the opportunity to serve as the analytical subject matter expert (SME) for internal product development, employing a range of analytical techniques such as chromatography (HPLC, UPLC, SEC), Electrophoresis, ELISA based methods and other standard methodologies to support preclinical stage large molecule projects.
- Lead method development, analytical testing and method qualification initiatives, encompassing protocol preparation, SOP review, technical report generation, and memo composition.
- Develop and implement methodologies and strategies for the quantitation, characterization, and stability testing of drug substances and drug products.
- Responsible to develop bio-analytical methods for testing and characterization of protein therapeutics such as ELISA, SPR, BLI and various cell-based assays.
- Design and execute experiments to characterize biochemical and biophysical of protein therapeutics.
- Collaborate efforts in protein engineering to optimize stability, solubility, and other critical
- Able to evaluate, design and perform method development and qualification employing phase-appropriate approaches at different stages of development
- Maintain accurate, detailed, and timely notebook records of method development and analytical data
- Interact with internal partners, CROs and contract laboratories during the development of analytical methods, stability testing, and preparation or overview of technical transfer documents
- At Insmed, you'll find a culture as human as our mission-intentionally designed for the people behind it.
Requirements
- You have a B.S in Chemistry or Biochemistry with 8 years, M.S with 6 years or PhD with 3 years of experience in the biopharmaceutical industry.
- You are or you also have:
- Individuals must demonstrate the ability to interact successfully in a dynamic and culturally diverse workplace.
- Knowledge of laboratory safety and quality control practices
Nice to have
- Ability to define problems, collect data, and draw valid conclusions.
- Hands on experience using and interpreting data from various analytical techniques including but not limited to chromatography (HPLC, UPLC, SEC, GC, etc.), mass spectroscopy (LC-MS, GC-MS, etc.)
- experience with Waters/Empower is preferred.
- Experience with SEC-MALS and MS being advantageous.
- Good understanding of GxP, CMC, ICH and compendial (USP/EP/JP) regulatory requirements.
- Highly proficient in Microsoft Office (Word, Excel, PowerPoint, Outlook).
- Highly organized with a strong attention to detail, clarity, accuracy and conciseness.
- Must successfully exhibit Insmed's five (5) core values of Collaboration, Accountability, Passion, Respect, and Integrity along with any other position specific competencies.
Skills
- Strong statistical skills with a good understanding of basic and intermediate statistical tests.
- Excellent presentation skills both verbal and written.
Compensation
- Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)
- 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance
- $127,000.00-165,500.00 Annual
- Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established.
Benefits
- Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)
- Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration
- 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance
- Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities
- We do not discriminate in hiring on the basis of physical or mental disability, protected veteran status, or any other characteristic protected by federal, state, or local law.
Company info
- At Insmed, every moment and every patient counts - and so does every person who joins in.
- As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you'll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person's contributions to meaningful progress.
- That commitment has earned us recognition as Science magazine's No.
- 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.
- For patients, for each other, and for the future of science, we're in.
Equal opportunity
- Insmed Incorporated is an Equal Opportunity employer.
- Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities.
- To request reasonable accommodation to participate in the job application or interview process, please contact us by email at TotalRewards@insmed.com and let us know the nature of your request and your contact information.
- Requests for accommodation will be considered on a case-by-case basis.
This listing is sourced directly from Insmed's careers page and normalized into a canonical job model.