Valo Health

Valo Health

Scientist II, Discovery Chemistry and Automation (Parallel Synthesis)

Lexington, Massachusetts, United States · Mid

Work authorization required$123k-$145kDetected 22 days ago
Machine LearningData ScienceA/B Testing5G/LTEPharmacologyMass SpectrometryPublic Speaking

About the role

  • Our talented team of biologists, chemists and engineers, armed with advanced AI/ML tools, work together to break down traditional R&D silos and accelerate the speed and scale of drug discovery and development.
  • Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together.
  • Valo is headquartered in Lexington, MA, with additional offices in New York, NY and Tel Aviv, Israel.

Responsibilities

  • Design, prioritize, and execute focused and diverse compound libraries to address SAR hypotheses and project needs
  • Develop and implement parallel synthesis strategies to enable rapid library generation and iteration
  • Design and optimize synthetic routes that allow efficient diversification and scalability
  • Collaborate closely with Medicinal Chemistry, In vitro Pharmacology, Biology, DMPK, ML/AI, and Chemistry Data Science teams to guide compound design
  • Apply structure-activity relationship (SAR) insights to drive compound optimization
  • Perform compound synthesis, purification, and characterization (e.g., NMR, LC-MS) of intermediates for library synthesis on 1-5g scale
  • Document experimental work and communicate results through presentations and reports
  • Demonstrated experience in compound library design and synthesis
  • Experience collaborating with or managing CRO partners

Requirements

  • Hands-on experience with standard analytical techniques (NMR, LC-MS, HPLC)
  • Experience with parallel synthesis, library enumeration, reaction screening, or automated chemistry platforms

Compensation

  • for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience.
  • Valo Health currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.

Benefits

  • and benefits information is based on Valo Health's good faith estimate as of the date of publication and may be modified in the future.

Company info

  • Valo Health is a human-centric, AI-enabled biotechnology company working to make new drugs for patients faster. The company's Opal Computational Platform transforms drug discovery and development through a unique combination of real-world data, AI, human translational models and predictive chemistry.
  • Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together. We embrace new ways of learning, solve complex problems and welcome diverse perspectives that can help us advance patient-centric innovation.
  • Valo is headquartered in Lexington, MA, with additional offices in New York, NY and Tel Aviv, Israel. To learn more, visit www.valohealth.com.
  • We are seeking a highly motivated synthetic chemist to join our drug discovery team, with a focus on design, synthesis, and optimization of compound libraries.
  • This role will play a critical part in advancing programs from hit identification through lead optimization by enabling rapid and efficient exploration of chemical space.
  • Valo Health is a human-centric, AI-enabled biotechnology company working to make new drugs for patients faster.
  • The company's Opal Computational Platform transforms drug discovery and development through a unique combination of real-world data, AI, human translational models and predictive chemistry.
  • We embrace new ways of learning, solve complex problems and welcome diverse perspectives that can help us advance patient-centric innovation.
  • To learn more, visit www.valohealth.com.
  • About the Role...
  • You will work in a collaborative, cross-functional environment to design and execute singleton and library syntheses integrated into our closed-loop design (CLD) strategies, leveraging modern synthetic methodologies, automation, and computational tools to accelerate discovery.
  • Your primary areas of responsibility will be:
  • Utilize modern approaches such as high-throughput experimentation (HTE)
  • What You Bring…
  • Ph.D. (or equivalent experience) in Organic Chemistry, Medicinal Chemistry, or related field (or M.S. with 4-6+ years, B.S. with 6-8+ years relevant experience)
  • Strong expertise in synthetic organic chemistry within a drug discovery setting
  • Proven ability to solve complex synthetic challenges
  • You May Also Bring…

Visa & Work Authorization

  • At this time, we are only able to consider candidates who currently have permanent US work authorization without the need for immediate or future sponsorship.
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This listing is sourced directly from Valo Health's careers page and normalized into a canonical job model.